Toxicological Aspects of PROTACs

The present chapter provides an in-depth exploration of PROTACs, a unique class of drug-like compounds that induce targeted protein degradation within cells. It discusses the novel mechanism of action of PROTACs compared to traditional small-molecule inhibitors, highlighting their potential to target a wide range of proteins, including previously “undruggable” ones. The chapter emphasizes the importance of thorough safety evaluations in the development of PROTAC-based therapies, addressing challenges such as off-target effects, immunogenicity, and cytotoxicity. By examining the toxicological studies conducted on PROTACs, the chapter underscores the critical need to assess and mitigate potential toxicity issues to ensure the safety and efficacy of these promising molecules in therapeutic applications.