Understanding the Ubiquitin Proteasome System: History and Revolution
摘要
The Ubiquitin Proteasome System (UPS) stands as a cornerstone in the realm of cellular biology, orchestrating the regulated degradation of proteins essential for cellular homeostasis. This chapter embarks on a journey through the historical milestones that have shaped our understanding of UPS, tracing its roots from early observations to contemporary breakthroughs. Moreover, the chapter delves into the transformative impact of UPS research on various fields, ranging from cancer biology to neurodegenerative diseases, highlighting how deregulation of UPS contributes to pathogenesis. Also, this chapter illuminates the historical journey and revolutionary insights that have propelled our comprehension of UPS, underscoring its pivotal role in cellular physiology and disease mechanisms.