The comfort condition of the classroom users has a direct impact on their productivity level. And thus, it has become a major concern of the designers to enhance the visual and thermal comfort conditions of classroom spaces. This study presents a case of multi-objective optimization of classroom design for enhanced visual and thermal comfort. A representative classroom layout (the Indian Standard Recommendations for Basic Requirements of School Buildings in 1978) in warm humid climatic conditions was chosen for the analysis. Four design variables such as building orientation, window-to-wall ratio (WWR), glazing material type, and shading device were considered, and a parametric analysis of the same using response surface method (RSM) was carried out. The visual and thermal performance of the developed cases in the parametric setup was assessed with the help of Simulation Tool-Rhino and plug-in such as Honeybee and Grasshopper. The results obtained from the parametric analysis were considered for the optimization computation with the objectives, (1) thermal comfort—in predicted mean vote (PMV) scale, the value tends to 5 for comfort (2) Visual comfort—in useful daylight illuminance (UDI) scale with value in range 70–100% and tending to 100% for comfort. The optimized output for the considered case was observed to be (6.38 mm clear laminated glass, 65 cm horizontal shading device, 40% WWR, N-S orientation). This study put forward a methodology for design optimization projects for architects and designers. The study needs further refinements with the inclusion of more design variables.