Influence of Drug Properties and Routes of Drug Administration on Design of Sustained and Controlled Release Systems

To efficiently approach the site of action after administration, every therapeutic molecule requires a capable delivery system. In case of freshly developed new chemical entity for therapeutic purpose, the selection and development of suitable dosage form are very critical to get the maximal efficacy for the treatment of target disease. When we opt for traditional drug delivery systems, they generally offer instant release of incorporated drug without any control on the release rate. On the other hand, sustained release and controlled release delivery systems are out-and-out influential for their inimitable benefits, e.g., reduction in dosing frequency, superior bioavailability of incorporated therapeutics, extension of the duration of effective blood-plasma levels, minimal peak-to-trough concentration fluctuation, and reduced side effects associated with conventionally developed formulations.