Science, Technology, Engineering, and Mathematics (STEM) is a learning approach that integrates several scientific disciplines to solve a particular problem. STEM emphasizes aspects of collaboration, communication, problem-solving, critical thinking, and creative so it can foster students’ curiosity. Currently, there are many studies on STEM education conducted in Indonesia, but not many have evaluated the results, especially in mathematics learning. This study aims to describe the research trends related to STEM education in mathematics learning in Indonesia. The method of this study is a systematic literature review. There are 45 articles published from 2018 to 2023 that qualified the inclusion criteria. The data analysis technique is a descriptive qualitative. The data were analyzed based on the year of publication, the education level, the location of research, the method of research, journal indexed, integration pattern, technology used in STEM research, and STEM learning objectives. The research results of STEM education in mathematics learning in Indonesia showed that (1) 20 articles (43%) are published in 2022, (2) 28 studies (60.9%) are conducted in junior high school, (3) 27 studies are conducted in Java island, (4) the method most often used in the application of STEM in mathematics learning is the research and development method, (5) 16 articles were published in journal indexed by Sinta 2, (6) the most common integration is project-based learning, (7) technologies that are often used in implementing STEM are Wolfram Alpha and GeoGebra, and (8) the most achieved STEM learning objective is creative thinking ability. The results of this study can expand the knowledge of educators and researchers about how STEM education research is conducted in mathematics learning in Indonesia. Further research can be conducted by looking at several research variables such as the level of education, technology used, or learning objective in conducting STEM in mathematics learning.