Therapeutic Strategies and Challenges in the Management of Aspergillus Infections

The widespread presence of Aspergillus presents a significant challenge in both its prevention and management. Aspergillus commonly targets the lungs, especially in people with compromised immune systems, and can subsequently disseminate to other areas of the body. Aspergillus infections may also co-occur with other diseases due to a compromised immune system, such as tuberculosis and COVID-19, as well as in recipients of organ transplants. To effectively address aspergillosis in various parts of the body, a targeted diagnostic approach is essential. This chapter delves into past and current therapeutic interventions, shedding light on their strengths and shortcomings. Key milestones in medical progress include the discovery of vaccines, monoclonal antibodies (mAbs), and nanotechnology-based therapies. These treatments hold the potential to revolutionize the approach to combating Aspergillus infections.