O-GlcNAcylation in Neuronal Development, Neurodegeneration, and Neurological Disorders

As a posttranslational modification, O-GlcNAcylation is catalyzed to the serine or threonine residues of proteins by O-GlcNAc transferase (Ogt), which can be removed by O-GlcNAcase (Oga), and is abundant in the neuronal system. Ogt modifies a variety of proteins and regulates multiple biological processes during embryonic and postnatal neurogenesis, neuronal development, and brain function. Previous studies have shown that the dysregulation of O-GlcNAcylation is involved in diverse neurological disorders, including neurodevelopmental and neurodegenerative diseases. In this review, we have summarized the recent progresses about the function and related mechanisms of Ogt and O-GlcNAcylation with a focus in neurogenesis, neuronal development, and neurological diseases.