Frozen section analysis of the gynecologic tract is a complex task due to the number of organs, tumors, and entities involved. Correlation with the indication for surgery as well as knowledge of what specific information that the surgeon seeks must be understood for each consultation. Often, the specimen is complex, with many parts, requiring extensive pre-sectioning dissection and gross evaluation. Careful execution of this step is paramount for a successful intraoperative consultation. Awareness of the importance of a thorough gross evaluation, careful selection of samples, and the numerous histologic features associated with this endeavor is a must. Often, selection of multiple fragments of tissue for frozen analysis can help to identify subtle histologic clues upon microscopy. Routinely, two to three sections per specimen may be submitted. This chapter acts to serve as a quick reference to some of the more common epidemiologic, gross, and histologic features of some of the more common entities encountered in intraoperative consultation of the female reproductive system.