In the absence of any universally recognized framework for technology cooperation, inequalities between the developed and the developing world in Science, Technology and Innovation (STI) capacity and outputs have been insurmountable. In the contemporary context, the situation gets more complex due to the misaligned priorities of scientific research with SDGs which is also a prime concern of countries in the Global South. The existing difference in innovation capacities and performance across countries is taken as fait accompli and with minimum attention to the fact that in effect such disparities hamper the collective progress of humanity resulting in stubborn inequalities. This calls for technology cooperation and access to resources based on public good principles of knowledge creation. To enhance access, there has to be a greater appreciation for ‘solutions’ and their ‘impact’. This requires new frameworks to prepare humanity for a true knowledge society founded on equity and, at the same time, help knowledge enterprise to contribute to the deepening of the paradigm of equity itself.