Prostate Cancer and Noncoding RNAs: A Focus on miRNAs, lncRNAs, and circRNAs
摘要
Noncoding RNAs (ncRNAs) are a class of regulatory transcripts that play important functions in the pathogenesis of several cancer types, including prostate cancer (PCa). Within the framework of prostate cancer, non-coding RNAs have the capacity to function as either oncogenic or tumor-suppressive agents. ncRNAs have the potential to participate in the prostate cancer progression by influencing the signaling of the androgen receptor (AR), the degradation process of AR via ubiquitin-proteasome pathways, or other critical signaling pathways. This chapter provides a detailed review of the involvement of ncRNAs in the evolutionary processes of PCa, with a particular emphasis on their significance in the development of innovative biomarker profiles and targets for cancer treatment.