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Prostate Cancer, Apoptosis, Autophagy and Ferroptosis: Cell Death Mechanisms and Their Cross-talk

  • Mehrdad Hashemi,
  • Atena Sadat Hosseini,
  • Sajad Monjezi,
  • Saina Hasany,
  • Sara Binaei,
  • Mobina Nejat,
  • Hadis Melyani,
  • Nader Bashandeh,
  • Arash Matinahmadi,
  • Zoofa Zayani,
  • Sima Orouei,
  • Seyed Hesamoddin Bidooki,
  • Rasoul Raesi,
  • Najma Farahani,
  • Maliheh Entezari

摘要

A crucial mechanism for maintaining organismic homeostasis is cell death, which is the last cellular choice taken after intricate communications. When cells stop performing their essential life duties, it is called cell death. Typically, cell death is categorized as either controlled cell death (RCD) or accidental cell death (ACD). The irreversible end of life occurs at cell death. Involved in embryonic development, organ maintenance, and autoimmunity, it is also the fundamental physiological mechanism of all living things. Apoptosis, necroptosis, autophagy, and pyroptosis are all forms of “programmed cell death” that have been better understood in recent years, and we have also identified several important genes involved in these processes. However, the use of these various cell death processes in illnesses and their conversion is underexplored in these earlier studies. Overall, the area of cell death has made several important discoveries in the past few years, but there are still a lot of unanswered questions. The facts show that cell death is a complicated game, with a number of key players that can upset the cell environment’s delicate balance, switching it from anti-inflammatory to pro-inflammatory, and from survival to death. There will undoubtedly be thrilling new research in this area in the coming years, thanks to the exhaustive investigation of the intricate regulatory mechanism of cell death.