Tandem/MCR Click Chemistry in Organic Synthesis

Multicomponent click chemistry has emerged as a powerful synthetic strategy, enabling the rapid and efficient construction of complex molecular architectures from simple building blocks in a single reaction sequence. By integrating multiple click reactions, such as Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC), Ru-catalyzed azide-alkyne cycloaddition (RuAAC), this approach offers exceptional modularity, selectivity, and functional group compatibility. Multi-component click reactions facilitate the simultaneous formation of multiple bonds, streamlining the synthesis of diverse structures including macrocycles. This technique is particularly valuable in medicinal chemistry for drug discovery, materials science for creating advanced functional materials, and biochemistry for developing complex biomolecular assemblies. This chapter explores the benefits of multicomponent click chemistry, highlighting its transformative impact on synthetic efficiency, molecular diversity, and application breadth across various scientific disciplines.