Altered Glucose Homeostasis in Neurological Disorders

Glucose is the major circulating energy source for the adult brain. Therefore, dysfunction in glucose metabolism disturbs normal functioning of neurons and it has been observed in several neurodegenerative disorders (NDDs). A major focus in the field of neurodegeneration is about understanding the mechanisms underlying glucose metabolism, and the regulation of the process during disease onset and progression relieves the neurons from degenerative stress leading to suppression of disease. In this chapter, we highlight the alteration in glucose homeostasis in major neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, etc. We suggest that maintaining glucose metabolism can be a potential therapeutic target for the management of neurological disorders.