Calcifying Epithelial Odontogenic Tumor

A calcifying epithelial odontogenic tumor (CEOT), first reported by Pindborg in 1955, is a benign odontogenic epithelial tumor that may evolve into a malignant one. A calcifying epithelial odontogenic tumor is rare, accounting for about 1% of odontogenic tumors, and the mean age of onset is 36.9 years old, with no significant gender difference [1–3]. CEOT can be divided into two types, namely, intraosseous type (95%) and extraosseous type. The incidence of CEOT in the mandible is about twice that in the maxilla, and the molar area is the most commonly involved. CEOT is mainly characterized by local invasion and intratumor calcified amyloid substances. It is mostly clinically manifested as a painless mass, which gradually increases and causes later symptoms such as tooth loosening and displacement, occlusion disorder, and even maxillofacial deformity. On X-ray, CEOT usually presents as an irregular projection in the jaw bone, showing unilocular or multilocular [4–7]. The lesion may be accompanied by unerupted teeth and calcification foci of different sizes. CEOT is often misdiagnosed or relapses due to inappropriate treatment [8, 9]. Surgical resection is an effective method for the treatment of CEOT, which needs to be removed 0.5 cm outside the tumor boundary.