Giant Cell Granuloma

Giant cell granuloma (GCG) is also called giant cell reparation granuloma (GCRG). The incidence of GCG is very low, accounting for about 7% of benign bone lesions. GCG in the head and neck is rarely reported. In 1953, Jaffe first introduced giant cell granuloma of the mandible, including sphenoid bone, ethmoid bone, skull base, temporal bone, orbital bone and craniofacial bone [1–4]. There are also case reports of GCG in ossicles of hands and feet and long bones of limbs, etc. GCG usually occurs in front of the maxillary first molar and can occur in all ages. It often occurs in teenagers, with an average age of 15 years. There is no significant difference in incidence between men and women, and most of the patients have a history of traumatic infection. It is generally believed that GCG is a rare non-neoplastic benign lesion, a proliferative repair reaction caused by traumatic intraosseous hemorrhage and having local invasion [5]. Overall, the understanding of this disease is not comprehensive enough; further study is required.