Pathogenesis of Dementia
摘要
Dementia is a pathological condition characterized by intricate molecular and cellular mechanisms that result in cognitive impairment. Brain damage from a variety of sources, such as injury or disease, results in dementia, which is characterized by symptoms like memory loss and altered thinking. Cognitive dysfunction, memory loss, and personality changes are among the main symptoms. Understanding dementia highlights the role of pathogenic mechanisms by revealing aberrant alterations in the brain. These mechanisms include hypertension, ageing, atherosclerosis, tau protein abnormalities, and amyloid deposition. There are still unanswered questions regarding the molecular and cellular pathogenesis of dementia. Converging pathogenic mechanisms, including Alzheimer’s disease, amyloid deposition, ageing, atherosclerosis, and hypertension, are responsible for vascular cognitive impairment, another factor contributing to dementia. These mechanisms worsen cognitive function by exacerbating cerebrovascular disease.