In order to develop a synchronous grouting material with good comprehensive performance, this paper selected cement, fly ash, mineral powder and slag by orthogonal experimental design method to carry out the proportioning test research, which provided the most suitable slurry proportion for engineering construction. The effects of group proportioning on fluidity, compressive and flexural strength, impermeability and volumetric stability were investigated. The results show that the increase of mineral powder content improves the fluidity performance of the system; the slurry nodules with high cement dosage have higher mechanical properties and impermeability; the secondary hydration of fly ash plays a slower role, so it reduces the early strength of the material and increases the late strength; the slag reduces the impermeability and drying shrinkage of the nodules. The research focuses on the characteristics of synchronous grouting in a subway station construction project in Qingdao. It investigates the mechanical and engineering properties of a new type of material and applies it to the field of engineering control. To some extent, this material can replace cement and effectively prevent tunnel water leakage, reduce operation and maintenance costs, and extend the operation and maintenance cycle, showing significant potential for widespread application.