Aiming at the problem of weakening mechanical properties of conventional concrete due to damage, the present paper studies the effect of nano-active powder on the splitting strength of concrete before and after damage. The nano-active powder concrete was prepared by adding 1.5%, 2.0% and 2.5% nano-silica (NS) and nano-zirconia (NZ) respectively. Through the splitting test before and after the damage of the sample, the self-healing performance of the sample was studied with the recovery rate of the splitting strength as the index. The results show that nano-active powders NS and NZ can increase the splitting strength and its recovery rate. Compared with the control group concrete, the addition of nano-active powder effectively improved the recovery rate of concrete splitting strength, and the optimal content of nano-active powders NS and NZ are 1.5% and 2.0%, respectively. This study deepens the understanding of mechanical properties of nano-concrete.