Oral Microbiome and Its Implication on Systemic Diseases

The oral microbiome is an intricate assembly of microorganisms within the mouth, serving a vital function in maintaining human well-being. Recent advances in sequencing and metagenomic analysis have shed light on its composition and function, revealing its connection to systemic diseases. This chapter explores the relationship between systemic diseases and oral microbiome, highlighting the bidirectional impact of oral health. It begins with an overview of the oral microbiome, focusing on key microbial species and their roles in maintaining oral health. The chapter then examines how oral bacteria and their byproducts can disseminate throughout the body and potentially contribute to systemic diseases. Specific conditions like preterm birth, cardiovascular diseases, diabetes mellitus, and rheumatoid arthritis are explored to illustrate the influence of the oral microbiome on their development. In conclusion, this chapter provides a comprehensive understanding of the complex relationship between the systemic diseases and oral microbiome. It emphasizes the significance of oral health for overall well-being and advocates for collaborative efforts among dental, medical, and scientific communities to leverage the therapeutic potential of the oral microbiome in preventing and managing systemic diseases.