Management of PHPT in MEN 1 and MEN 2 Syndrome

Primary hyperparathyroidism (PHPT) is a common endocrine disease, and a few have syndromic associations with Multiple Endocrine Syndrome Neoplasia Type 1 and Multiple Endocrine Neoplasia Type 2. Multiple Endocrine Neoplasia Type 1 (MEN 1) is characterised by neoplasms of parathyroid glands, pituitary, and gastro-pancreatic endocrine cells with phenotype expression of two or more organs. The PHPT is the commonest presentation of MEN 1. MEN 2 is the association of medullary thyroid cancer, pheochromocytoma, and neoplasms parathyroid. Usually, hyperparathyroidism associated with MEN 2 is mild and asymptomatic. PHPT is frequently encountered as expression mutations in exon II, codon 634 of MEN 2. The treatment of choice is excision of the enlarged parathyroid gland [1, 2].