Organic semiconductor devices have great potential in large-area fabrication using a complete solution processing method. The device performance is susceptible to the solvent used for preparing the precursor for the active layer. In this work, we have fabricated a polymer bulk heterojunction solar cell by spin coating the active layer precursor with different solvents, keeping all the fabrication parameters (solution concentration, spin speed and time, annealing temperature and time, etc.) constant. We have prepared precursors for the active layer in three different solvents (dichlorobenzene (DCB), toluene, and a mixture (1:1) of DCB and toluene) and analyzed the effect of solvents on the device performance. The film’s structural analysis is done with atomic force microscopy and field emission scanning electron microscopy. Considerable variation in viscosity and evaporation rate of solvents causes significant variation in film thickness, surface roughness, and degree of disorder. The absorption spectrum for all the films remains the same and is not affected by changing the solvent. Consequently, the device’s electrical performance varies in accordance with the used solvent.