Genomic Precision: Unveiling the Transformative Role of Genome Editing in Advancing Genomics Research and Applications

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发表日期：

2024年

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Gholamreza Abdi,
Nil Patil,
Prachi Mishra,
Mohd. Tariq,
Rupal Dhariwal,
Shaista Parveen,
Kirtan Dave,
Mukul Jain,
Maryam Abbasi Tarighat,
Gaurav Mudgal

摘要

Genomic precision has emerged as a hallmark in contemporary genetics, reshaping the landscape of genomics research and applications. Genome editing, with its unparalleled ability to precisely manipulate DNA sequences, stands as a transformative tool driving this revolution. This abstract explores the multifaceted impact of genome editing techniques, such as CRISPR-Cas9, TALENs, and zinc finger nucleases, in unraveling the intricacies of the genome and fostering groundbreaking advancements in diverse fields. Genome editing technologies have revolutionized functional genomics by enabling targeted modifications of DNA sequences with unprecedented accuracy and efficiency. These tools have not only expedited the elucidation of gene function and regulatory mechanisms but have also facilitated the creation of disease models for understanding pathophysiology and drug discovery. Moreover, the transformative potential of genome editing extends beyond fundamental research to clinical applications, offering promising avenues for treating genetic disorders, cancer, and infectious diseases. The ability to precisely correct disease-causing mutations holds immense therapeutic promise, ushering in an era of personalized medicine tailored to individual genetic profiles. Furthermore, genome editing has catalyzed agricultural innovation by facilitating the development of genetically modified crops with enhanced yield, nutritional value, and resilience to environmental stressors, thereby addressing global food security challenges. In conclusion, the advent of genome editing technologies has revolutionized genomics research and applications, offering unprecedented precision and versatility in manipulating the genetic blueprint of living organisms. By unlocking the intricacies of the genome, genome editing holds the key to addressing pressing challenges in medicine, agriculture, and beyond, shaping the future of genomic precision and its transformative impact on society.