Recent Advances in Plasmonic Biosensors for Digital Healthcare Applications

The field of biosensing technology has witnessed remarkable advancements in recent years, particularly with the emergence of plasmonic biosensors. This abstract represents the recent strides in plasmonic biosensing and its pivotal role in revolutionizing digital healthcare applications. Plasmonic biosensors harness the unique properties of surface plasmon resonance (SPR) and localized surface plasmon resonance (LSPR) to enable highly sensitive, label-free, and real-time detection of biomolecules. This review delineates the fundamental principles underlying plasmonic biosensors, elucidating the interaction of electromagnetic fields with nanostructured metal surfaces, leading to enhanced sensitivity and specificity in detecting analytes. Moreover, it highlights the integration of plasmonic biosensors with digital healthcare platforms, facilitating point-of-care diagnostics, continuous monitoring, and personalized healthcare. Key technological breakthroughs in plasmonic biosensing architectures, including nanoparticle-based sensors, plasmonic waveguides, and nanostructured surfaces, are examined, emphasizing their role in achieving ultrahigh sensitivity and specificity. Additionally, the incorporation of novel materials and fabrication techniques has expanded the versatility and robustness of plasmonic biosensors, paving the way for multifunctional and portable devices suitable for remote healthcare settings. Furthermore, this abstract underscores recent applications of plasmonic biosensors in digital healthcare, encompassing early disease diagnosis, monitoring of biomarkers, detection of pathogens, and drug screening. The integration of these sensors with digital platforms and smartphone-based interfaces has enabled real-time data acquisition, analysis, and transmission, fostering the paradigm shift toward connected and accessible healthcare solutions. The challenges and future prospects in the field are also discussed, addressing issues related to scalability, cost-effectiveness, and standardization for widespread adoption in clinical settings. Anticipated advancements in nanofabrication techniques, material engineering, and signal processing algorithms are envisioned to further propel the integration of plasmonic biosensors into the digital healthcare landscape, thereby revolutionizing healthcare delivery and disease management. Plasmonic biosensors with digital healthcare technologies hold immense promise in transforming the landscape of diagnostics and personalized medicine, offering unprecedented opportunities for enhancing healthcare accessibility, efficiency, and patient outcomes.