The chapter provides a comprehensive overview of hepatobiliary interventional techniques, emphasizing their pivotal role in modern clinical medicine. Interventional radiology (IR) utilizes image-guided equipment such as ultrasound, X-ray, CT, and MR to employ interventional tools like puncture needles, catheters, and guide wires for diagnostic and therapeutic purposes. These minimally invasive and targeted techniques are indispensable in diagnosing and treating both tumor and nontumor diseases within the hepatobiliary system. Key methods include vascular and nonvascular interventional radiology with specific applications in hepatic arterial chemoembolization as well as various physical ablation techniques including radiofrequency ablation and argon-helium cryoablation. These methods demonstrate efficacy particularly for tumors with rich blood supply and small hepatocellular carcinomas; however, they have distinct indications and contraindications. Advanced techniques such as percutaneous transhepatic cholangial drainage (PTCD) and trans ugular intrahepatic portosystemic shunt (TIPS) further expand the therapeutic arsenal by providing solutions for obstructive jaundice, variceal bleeding, and refractory ascites. The chapter highlights the evolving landscape of interventional radiology while suggesting that continuous technological advancements along with combined treatment approaches could enhance the efficacy and safety of these minimally invasive procedures.