Amyloidosis is a disease of protein metabolism, caused by amyloid deposition in the liver. It can be divided into primary, secondary, dialysis-related, familial, senile, and primary and secondary amyloidosis are the most common. Ultrasound/CT/MRI is used to screen for liver amyloidosis and rule out diseases other than liver amyloidosis. Pathology is still the “gold standard” for the diagnosis of hepatic amyloidosis. This diagnosis should be considered when the clinical manifestations are significant liver enlargement, significant elevation of alkaline phosphatase, minor impairment of other liver functions, detection of monoclonal proteins in urine or blood, or evidence of primary systemic amyloidosis elsewhere in the body.