Heteroproliferative nodules (DN) are hepatocellular nodules more than 1 cm in diameter with abnormal cellular and nuclear proliferation that do not yet meet histologic criteria for malignancy. DN are classified according to the degree of cellular heterogeneity into low-grade (LGDN) and high-grade (HGDN), of which HGDN are considered precancerous with a higher propensity to malignant transformation. LGDN exhibit mild cellular heterogeneity and usually have no obvious nodal structure, while HGDN have more pronounced cellular and structural heterogeneity and may contain “nodules within nodules.” LGDN exhibits mild cellular heterogeneity and usually has no obvious nodal structure, whereas HGDN has more pronounced cellular and structural heterogeneity and may contain “nodules within nodules.” Imaging shows that the DN tends to be isointense on CT plain scans, and on enhanced scans, the LGDN usually has no significant enhancement in the arterial phase, whereas the HGDN may have mild enhancement. On MRI, the LGDN has variable signals on T1WI and T2WI, whereas the HGDN may have mild enhancement in the arterial phase. On ultrasound, LGDN tends to have a “slow in, equal out” pattern, while HGDN tends to have a “fast in, equal out” or “slow in, equal out” pattern. The diagnosis of DN should be combined with imaging and pathologic examinations to differentiate it from regenerative nodules (RN) and hepatocellular carcinoma (HCC).