Regenerative nodules (RN) are focal hyperplasia of hepatocytes and interstitium, usually less than 1 cm in diameter. Hepatic cells in nodules have steatosis, cholestasis, bile pigment, and hemosiderin deposits, cells with different degrees of inflammation in the fibrous septum. The blood supply is similar to that of normal hepatocytes, mainly in the portal vein, with a small amount of arterial blood supply. Nodules with diameter of iron deposition greater than 8 mm are more prone to malignant transformation than nodules without iron deposition. Fatty RNs larger than 1.5 cm in diameter (T1WI with high signal and T1WI with weakened anti-confidence signal) are highly malignant and should be followed up within a short period of time (3–6 months). Ultrasound showed that hyperechoic nodules were common and hypoechoic nodules were also visible. The imaging showed “wait-in and wait-out” mode.