Liposomes as a Potential Carrier for Brain Delivery

In the present scenario, macromolecules and more than 97% of small particle compounds are unable to reach across the BBB, which results the deprived pharmacodynamic and pharmacokinetic profile of concerned drugs. In this view, the nanotechnology can play a significant role to overcome the stated problem. Recently, nanoparticles are dragging lots of interest as nanodelivery system carries the drug into the brain because it provide stability for drug metabolism in organ fluid as well as the enzyme metabolism. Out of various nanodelivery systems, the liposome is the most classical approach for drug delivery to the brain. The limitation of conventional formulations such as lower aqueous solubility, lower availability in circulation, and uncontrolled specific distribution in biological site, can be solved by the use of liposomes. Liposomes are also derivatized by functionalization of their surface with polyethylene glycol, polysaccharides, peptides, or antibodies, which helps to improve the circulation time and specificity for brain delivery. This chapter highlights studies on liposome-based techniques for successful medication administration across the blood–brain barrier. It may be concluded that the development of liposomes for brain administration is still in its early stages, despite the fact that these systems have the potential to transform how medicine is provided.