In Vivo Animal Models Development and Their Limitations for Brain Research

In vivo animal models play a crucial role in advancing our understanding of the complexities of the brain and neurological disorders. This abstract explores the processes involved in the development of such models and sheds light on the inherent limitations that researchers face in utilizing these models for brain research. The establishment of reliable animal models involves careful consideration of species selection, genetic manipulations, and behavioral assessments to ensure translational relevance to human conditions. While these models have significantly contributed to our comprehension of neurobiological mechanisms and the development of potential therapeutic interventions, several limitations hinder their efficacy. Variability in genetic backgrounds, ethical concerns, and differences in brain anatomy and physiology between animals and humans pose challenges in extrapolating findings from animal studies to clinical applications. Additionally, the limited ability to mimic the intricate neural networks and cognitive functions of the human brain remains a major obstacle. This abstract also delves into the ethical considerations surrounding the use of in vivo animal models, emphasizing the importance of responsible research practices. In this chapter, a comprehensive overview of the development and utilization of in vivo animal models in brain research, highlighting their invaluable contributions while acknowledging the inherent limitations were explained.