Optimizing Oncology Tools: Organ-On-A-Clip Alternative to Animal Model

The infamously extreme attrition of existing drug discovery and development are driving a paradigm change in biomedical research toward methods centred on human illness models. The fundamental forces behind this shift are shortcomings of animal models, which are still the gold standard for preclinical and basic research but have trouble accurately simulating human physiological and pathological circumstances due to interspecies differences. High clinical mimicking bioengineered human disease models are being created to close this translational gap. Progress in bioengineering has resulted in intricate human illness models that closely resemble clinical conditions and have a high level of predictability. Despite numerous studies in the fields of oncology and therapeutics, cancer remains a significant threat. Understanding the underlying biology of cancer and developing effective treatments is challenging due to the elusive molecular processes of tumors and the intricate in vivo microenvironment they inhabit. As a result, novel methodologies are imperative in order to progress the effective management of cancer, particularly in understanding how the diverse tumors microenvironment (TME) influences individual patient responses to cancer drugs. Organ-on-a-clip (OoC) technology represents a cutting-edge advancement with the potential to revolutionize personalized medicine and enhance the discovery of more effective medications. A functional models developed in a laboratory setting with the aim of replicating an organ's natural functions, represent Organ-on-a-clip platform, mimic tumors microenvironment and its function. OoC emerging method for simulating invivo physiological condition for cell culture model and preclinical animal models to study the disease condition. The goal of the current chapter is to deliver a brief compilation of Organ-on-a-clip cutting edge technology for the understanding of complex, challenging, difficult to treat clinical condition of cancer and future prospective future roles in the field of medical sciences/biotherapeutics.