Advanced Systems and Bioreactors for Large-Scale Secondary Metabolite Production in Medicinal Plants Using Suspension Cultured Cells

In recent years, there has been extensive research on large-scale plant secondary metabolite production systems and bioreactors for various applications in the environmental, medical, and pharmaceutical fields. The cell suspension culture system is proven to be more efficient in obtaining uniform cell populations, screening for mutant individuals, and conducting large-scale cultures for the production of secondary metabolites. Currently, cell suspension culture-based systems and bioreactors are being developed for the large-scale production of secondary metabolites from medicinal plants. The objective of this paper is to provide a comprehensive understanding of recent advancements in the large-scale production of secondary metabolites using suspension cultured cells. This includes the exploration of novel bioreactor designs, optimization of cultivation conditions, and development of innovative strategies to increase the productivity of secondary metabolites from medicinal plants. The findings in this paper can serve as a reference for future research and the commercialization potential of secondary metabolite bioreactors. Furthermore, it aims to lay the foundation for continued research in the application areas of medicinal plants, the development of optimized production systems for these secondary metabolites, and the enhancement of their industrial productivity.