Solid-State Cross-Coupling Reactions of Insoluble Aryl Halides Under Polymer-Assisted Grinding Conditions

In this study, polymer-assisted grinding (POLAG), a ball milling technique based on the use of polymer additives, was applied to mechanochemical solid-state Suzuki–Miyaura cross-coupling reactions of insoluble aryl halides. The author found that the efficiency of this challenging solid-state cross-coupling was successfully improved by the addition of polytetrafluoroethylene (PTFE) as a POLAG additive under high-temperature ball-milling conditions. My results suggest that POLAG is a promising approach for controlling the reactivity of insoluble substrates that are barely reactive under conventional solution-based conditions.