Left Ventricular Wall Stress of Myocardial Infarction Patients During Filling

Myocardial infarction (MI) is an ischaemic heart disease in which myocardial tissues experience oxygen shortage, leading to heart muscle injury or necrosis. This study aims to investigate the regional wall stresses and strains during the filling phase in cylindrical coordinates using patient-specific left ventricular (LV) models. Finite element (FE) models of one healthy subject and one MI patient were constructed using the patient-specific LV geometries to simulate the filling phase. Regional end-diastolic wall stresses and strains were quantified in circumferential, longitudinal and radial directions. Based on the results, the MI model showed abnormal high wall stresses (5 to 9 kPa) and strains (0.32 to 0.40) in all directions, not only at the border zone (BZ) but also its adjacent remote zone (RZ) as compared to the healthy model (stress: 1.6–4.4 kPa, strain: 0.16–0.26). These adverse high regional stresses and overstretching could impose a risk of LV remodelling.