Cancer Drug Resistance and Metabolic Reprogramming

There is a complex and strong association between metabolic reprogramming and the phenomenon of drug resistance in cancer. Cancer cell metabolic modifications and crosstalk with cellular and noncellular components are essential to support their growth and proliferation and support anticancer therapy resistance. The chapter explores the unintended consequences of chemotherapy interventions, revealing how therapeutic measures can induce metabolic shifts in cancer cells that inadvertently contribute to the emergence of chemoresistance. The chapter navigates through the complicated interplay between key genetic players and the metabolic shifts that support drug resistance mechanisms. Finally, the chapter proposes innovative strategies to manipulate cancer cell metabolism as a promising avenue for overcoming drug resistance. This comprehensive examination not only elucidates the complex link between metabolic reprogramming and drug resistance but also suggests potential therapeutic interventions, presenting a roadmap for future research in the evolving landscape of cancer treatment.