Role of Cancer Stem Cells in Drug Resistance

The chapter on the “Role of Cancer Stem Cells in Drug Resistance” explores the intricate mechanisms underlying the resistance of cancer stem cells (CSCs) to therapeutic interventions. CSCs, a subpopulation within tumors endowed with self-renewal and differentiation capabilities, have been implicated in the persistence and recurrence of cancers. Moreover, the role of CSCs in promoting tumor heterogeneity and driving metastasis further complicates treatment strategies. The chapter explores the multifaceted ways in which CSCs contribute to drug resistance, including enhanced DNA repair mechanisms, activation of antiapoptotic pathways, and the ability to evade immune surveillance. It also explains the unique features of CSCs that differentiate them from typical cancer cells. The chapter examines recent advancements in targeting CSCs to overcome drug resistance, emphasizing the importance of developing novel therapeutic approaches that specifically address the unique biology of CSCs.