Novel Strategies for Overcoming Drug Resistance

This book chapter explores novel strategies for overcoming drug resistance in cancer, focusing on advancements in drug delivery using nanoparticles (NPs) and CRISPR-based techniques. Nanoparticles offer targeted delivery, improving drug bioavailability and minimizing off-target effects. The chapter reviews recent developments in NP-based formulations designed to overcome resistance mechanisms, emphasizing their potential to enhance therapeutic efficacy. CRISPR technologies enable targeted modifications to the cancer cell genome, disrupting resistance-associated pathways and sensitizing cells to treatment. The chapter evaluates CRISPR-based interventions, discussing their potential to tackle intrinsic and acquired resistance mechanisms. By synthesizing these two cutting-edge approaches, this chapter presents an integrative view of how nanoparticle drug delivery and CRISPR-based strategies can synergistically address drug resistance challenges in cancer therapy.