Effects of Buffers Over the Cytosolic Calcium Concentration

In this chapter, we study the change in cellular calcium with different buffers. The study is carried over the advection–diffusion equation framed for the cellular calcium with inclusion of buffers. The level of cellular calcium gets lowered down in the presence of buffers. Buffers bind to the free calcium ions and play a vital role in lowering the cytosolic calcium concentration level and hence prevent the toxicity of calcium within the cell. The model includes buffer concentration, association rate, diffusion coefficient, and dissociation rate. For the developed model, effects of various buffers on the calcium concentration distribution are observed through simulation.