Oxidative Phenolic Coupling Reaction/Aza-Michael Reaction Strategy for the Synthesis of Complex Polycyclic Alkaloids

The synthesis of alkaloids featuring fused polycyclic frameworks has long attracted the interest of synthetic organic communities, owing to their great structural complexity and wide variety of biological activities. Indeed, a variety of strategies for synthesizing these alkaloids have been investigated over the years. Here, we present our innovative strategy for tahe construction of complex fused polycyclic frameworks via oxidative phenolic coupling reaction and subsequent regioselective intramolecular aza-Michael reaction. We illustrate its practical application in synthetic studies of amaryllidaceae alkaloids, and hasubanan alkaloids.