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Pathogen infections pose a serious threat to human health, and the overuse of antibiotics has exacerbated the difficulty of treating these pathogens. Photodynamic therapy (PDT), as a noninvasive and low-resistance treatment method, has garnered widespread attention. The development and utilization of aggregation-induced emission luminogens (AIEgens) provide reliable photosensitizers (PSs) for PDT and fluorescence imaging. Molecules based on tetraphenylethylene (TPE) and triphenylamine (TPA) are well-studied AIEgens that can be used as electron donors to construct various AIE PSs with high reactive oxygen species (ROS) generation efficiency and fluorescence imaging capabilities. Herein, we mainly review the applications of AIEgens containing TPE and TPA skeletons in the antibacterial field in recent years, aiming to provide reference for the design of effective AIE PSs.

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AIEgens Based on Tetraphenylethylene and Triphenylamine for Photodynamic Antimicrobial Therapy

  • 动态工具书词条

  • 发表日期：

    2025年

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  • Huanxiang Yuan,
  • Haorun Song,
  • Haotian Bai

摘要

Pathogen infections pose a serious threat to human health, and the overuse of antibiotics has exacerbated the difficulty of treating these pathogens. Photodynamic therapy (PDT), as a noninvasive and low-resistance treatment method, has garnered widespread attention. The development and utilization of aggregation-induced emission luminogens (AIEgens) provide reliable photosensitizers (PSs) for PDT and fluorescence imaging. Molecules based on tetraphenylethylene (TPE) and triphenylamine (TPA) are well-studied AIEgens that can be used as electron donors to construct various AIE PSs with high reactive oxygen species (ROS) generation efficiency and fluorescence imaging capabilities. Herein, we mainly review the applications of AIEgens containing TPE and TPA skeletons in the antibacterial field in recent years, aiming to provide reference for the design of effective AIE PSs.