High Order Conditional Random Field Based Cervical Cancer Histopathological Image Classification

Cervical cancer ranks as the fourth most frequently diagnosed cancer. This disease has an extended precancerous stage and can be completely cured and prevented through early detection. Currently, the analysis of histopathological images of cervical cancer relies on manual assessment by pathologists, a subjective and time-consuming process. Moreover, there is limited research on differentiating the severity of cervical cancer in histopathological images. To address these challenges, this study proposes a classification algorithm based on high-order conditional random field for cervical cancer histopathologic images. The algorithm effectively categorizes images into high differentiation, medium differentiation, and low differentiation stages. Three deep learning models, namely VGG-16, Inception-V3, and ResNet-50, are utilized for pre-classification at the image block level. For image-level classification, the Visual Transformer model is employed. Finally, the block-level and image-level classification components are integrated using the conditional random field model, resulting in the high-order conditional random field model. Following training and testing using the dataset, the model achieves an overall accuracy of 75.4%.