This chapter outlines the contributions of the health and medical humanities to health behaviors, health promotion, and illness prevention. The medical humanities developed in response to the increasing focus on science in medical education at the expense of humanizing factors. Focusing on the training of physicians, the medical humanities initially served to introduce the humanities and arts to medical students and then developed into disciplinary status with their own critical approaches to the intersections of the humanities and arts to medicine. The health humanities were formalized in recent decades to recognize the breadth of health concerns, approaches, practices, and understandings that exist outside the boundaries of formal biomedical contexts. Central qualities of the health and medical humanities are established, and these fields of intellectual inquiry, research, and health and clinical application are situated within the realm of health broadly conceived. The chapter accounts for the important role the health and medical humanities have in individual and communal health, in institutional and formal medical and health contexts, and in the promotion of positive health outcomes. By examining select applications of the health and medical humanities, this chapter serves to illustrate the immense potential of these fields to deploy a human-centered understanding of health and wellness. Key topics such as narrative medicine, pathography (illness narratives), the arts, and disability are examined as they relate to understanding of how individuals situate their health in the world. Further, the health and medical humanities are situated in relation to medical and other clinical practice, health contexts adjacent to institutionalized spaces, and the education of healthcare professionals.