The Application of 4-Hexylresorcinol in Tissue Engineering

This chapter explores the potential applications of 4-hexylresorcinol (4HR) in tissue engineering, focusing on its use in silk fibroin membrane (SFM), bone graft materials, vessel regeneration, and inhibition of foreign body reactions. The incorporation of 4HR into SFM demonstrated improved bone regeneration and an acceleration of partial degradation of the SFM. However, further research is required to determine if complete resorption can be achieved. Additionally, the chapter discusses the development of 4HR-incorporated bone graft materials, including the combination of 4HR with hydroxyapatite, porcine bone, bovine bone, and sericin. These materials show promising results in enhancing bone formation and vessel regeneration while inhibiting foreign body reactions. Despite these promising findings, more research and human clinical trials are necessary to confirm their efficacy and safety. Overall, this chapter highlights the potential of 4HR-incorporated materials in tissue engineering and provides a foundation for future investigations in this area.