4-Hexylresorcinol as Histone Deacetylase Inhibitor

This chapter investigates the role of 4-hexylresorcinol (4HR) as a histone deacetylase inhibitor (HDACi) specifically targeting Class I and IIa HDACs and its potential therapeutic applications. While 4HR does not directly inhibit Class III HDACs (sirtuins), it has been observed to impact the expression of SIRT3 and 6 through other mechanisms, such as modulating NAD+ levels. The chapter also delves into the effects of 4HR on growing animals, emphasizing the gender-specific influences on body weight, mandibular size, and hormonal levels. These findings underscore the complex relationship between 4HR, its HDACi activity, and hormonal regulation. Further research is needed to better understand the mechanisms behind these effects and to explore the full therapeutic potential of 4HR as an HDACi.