Smart Development of Nano Materials and Nanomedicine Formulations

The field of nanotechnology has brought in a giant revolution and nanomedicine has emerged as a key player in offering cross-sectoral and cross-technological solutions for various treatment modalities. The domain of nanomedicine includes the nanocarriers and the nanomaterials themselves. The new generation of nanomaterials with their unique properties (acoustic, electrical, mechanical, optical) has unique interactions in the biological milieu. This has undoubtedly opened up new clinical perspectives for better management of various diseases and disorders. Over 50 formulations based on nanotechnology have reached the market and are approved as anesthetics, anti-cancer therapies, anti-fungal, and iron-replacement therapies among others. But, the development of nanomedicine that has the desired and reproducible functionalities, and can successfully transit from bench to bedside is a tedious, rigorous, and arduous pursuit. The Fourth Paradigm of scientific research including rational design, high throughput experimental techniques, process automatization, artificial intelligence technology, and machine learning has immense potential to be integrated with nanomedicine/nanomaterial research to achieve smart products having the desirable features. The chapter would cover the concepts, historical evolution, and application of these smart nanomaterials, implementation of AI in healthcare, biosensors/smart sensors in neurodegenerative diseases, telemedicine, and its fine-tuning to generate nano pharmaceuticals with requisite profiles to enable their successful clinical translation.