Entrepreneurship in dentistry integrates clinical proficiency, strategic business management, and technological innovation. As the profession evolves from a service-centric model to a complex healthcare enterprise, entrepreneurial competencies are increasingly essential for clinicians, educators, and policymakers. This chapter delineates the theoretical constructs of entrepreneurship within dentistry, identifying core traits and strategic approaches that define successful dental entrepreneurs. It categorizes entrepreneurial pathways into practice ownership, specialist services, educational ventures, technological innovation, and socially driven models addressing oral health disparities. Key business principles, including financial planning, marketing, human resource management, and regulatory compliance, are systematically reviewed. The transformative impact of technologies such as computer-aided design and manufacturing (CAD/CAM), three-dimensional (3D) printing, and artificial intelligence in dentistry is critically examined in the context of emerging business models. Ethical leadership and sustainability are emphasized as foundational to balancing commercial viability with patient welfare. The chapter concludes by projecting future trends, including digitalization, teledentistry, and corporate integration, and advocates for embedding entrepreneurial training in dental curricula. Case studies illustrate applied entrepreneurship, reinforcing its role in advancing clinical innovation, healthcare access, and the long-term viability of the dental profession.