This chapter reviews the development, implementation, and future perspectives of Objective Structured Clinical Examinations (OSCEs) in healthcare education. It traces the evolution of assessment methods from traditional oral and clinical examinations to the standardized OSCE format introduced in the 1970s to improve reliability and objectivity. OSCEs are defined as structured, station-based assessments evaluating a wide range of clinical competencies. Their relevance across healthcare professions is emphasized, particularly for quality assurance, professional development, and patient safety. Guidance is provided on designing OSCEs, including blueprint creation, scenario construction, scoring methods, and pilot testing to ensure validity and fairness. Implementation logistics and roles of examiners, simulated patients, and administrative staff are outlined, alongside considerations for security and evaluation consistency. The chapter further highlights student preparation strategies and the psychological impact of OSCE-related stress. Digital innovations such as virtual OSCEs and serious games are examined as tools for training and assessment, offering flexibility but also presenting technical and pedagogical challenges. Additionally, the potential integration of artificial intelligence into assessment processes is discussed. Overall, OSCEs are presented as a robust yet evolving assessment model that must adapt to technological advancements and changing healthcare demands.