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Molecular Devices that Support Genome Processing

  • Shigeki Mitaku,
  • Ryusuke Sawada

摘要

A variety of molecular devices are involved in proteins, which shape their structure and function. Among them, the group of molecular devices involved in genome processing is the most important. First, there are processes such as replication, transcription, and translation that directly process the genetic information written in the genome sequence to form proteins. Chaperones and translocons then form the three-dimensional structure of the protein from the synthesized amino acid sequence. In eukaryotes, cells are large, contain a variety of organelles, and have several intracellular processes. The genome is folded very compactly and stored in the nucleus. Folding of the genome itself is also performed by protein assembly. Then, there is an RNA editing process called splicing. The nuclear membrane contains nuclear pores that specifically transport nuclear proteins synthesized in the cytoplasm into the nucleus. The various mutations and their repair processes are important in terms of finalizing the genome sequence.