Analysis of Viruses, and the Fusion of Biology and Physics Through the Phase Diagram of Life

The study of genome sequences by the phase diagram of life is still in its early stages. One of the major remaining questions is whether viruses are living organisms in terms of their genome sequences. Both viruses and organisms have genome sequences. However, because they have very different life cycles, we do not know if the genome of a virus is in the same region of nucleotide composition space as that of a group of organisms. Therefore, we analyzed where the genome sequence of COVID-19 is located in the nucleotide composition space and how it migrated after becoming zoonotic. As a result, we first found that the viral genome is located in the phase diagram of life. After the virus became zoonotic, the genome sequence moved unilaterally within the nucleotide composition space. This change can apparently be explained by the fact that when the virus has changed hosts, the targets of nucleotide composition have changed. At the end of this book we listed the remaining questions.