The most realistic experimental method for evaluating the behavior of reinforced concrete structures under ground motion is the shaking table test. However, the construction of RC shaking table test specimens is costly, and the shaking table equipment has limited capabilities, making it difficult to conduct tests on large structures. In view of this, this paper proposes the development of a hybrid testing technique that combines numerical simulation with large-scale structural experiments to test the nonlinear response of large RC structures under strong ground motion more economically. This paper uses open-source hybrid testing technology, Open System for Earthquake Engineering Simulation, which is a finite element analysis software framework, to build a nonlinear RC numerical structure and Open Source Framework for Experimental Setup and Control, a middleware software package, to connect the numerical model with a physical structure and experimental control data. The prototype structure is a half-scale seven-story RC building, previously analyzed at the National Center for Research on Earthquake Engineering using shaking table tests in order to understand the dynamic response of RC structures under near-fault ground motions. The purpose of this paper is to use the open-source hybrid testing framework to reproduce the shaking table test results of this seven-story RC building. In addition to comparing the experimental results with theoretical analysis, the hybrid testing results are also compared with the shaking table test results. The results show that the nonlinear hybrid testing method used in this paper reproduces the shaking table test results and that the error between them is not significant, with a story drift error of 2% on the first floor.