Wound healingWound healing is a complex, multi-phase process that involves hemostasis, inflammation, proliferation, and remodeling to restore skin integrity and function. Effective wound management, especially in controlling bleeding and promoting tissue regeneration, remains a critical challenge in clinical care. Cellulose-based hemostaticHemostatic agents have gained attention for their role in wound healing due to their biocompatibility, biodegradability, and ability to form highly absorbent hydrogelsHydrogel. The use of hemostatic agents is crucial in preventing substantial blood loss and reducing the risk of death from excessive bleeding during surgical procedures or in emergency situations. These agents, derived from natural cellulose or modified nanocellulose, exhibit excellent fluid retention, structural stability, and the capacity to promote clotting, making them valuable in bleeding control. Furthermore, oxidized celluloseOxidized Cellulose (OC) is a highly effective biodegradableBiodegradable and biocompatible derivative of cellulose, making it one of the most widely used hemostaticHemostatic agents in surgical procedures. Moreover, the hemostatic properties of cellulose-based materials can be further enhanced through chemical modifications and incorporation of bioactive compounds, leading to improved antibacterial activity and accelerated healing. By creating a moist environment, these agents not only support cell proliferation but also reduce the risk of infection. This chapter reviews the design, mechanisms, and applications of cellulose-based hemostaticHemostatic agents in wound care, highlighting recent innovations and their impact on enhancing wound healingWound healing outcomes.